Vinyl Chloride (VC) is a proven human carcinogen and a major risk factor in many contaminated aquifers. substance or exposure is only on one agency’s list, this it does not necessarily mean there is a controversy, as one agency may not have evaluated The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. It does not occur naturally and must be produced industrially for its commercial uses. Vinyl bromide appears to be a more potent inducer of hepatic hemangiosarcoma in rats than is vinyl chloride. Some strains of obligate organohalide respiring Dehalococcoides mccartyi can synthesize the VC reductase that catalyzes the dechlorination of VC to ethene. Vinyl chloride is used primarily to make PVC, a substance used in products such as pipes. Vinyl chloride exposure is associated with an increased risk of a rare form of liver cancer (hepatic angiosarcoma), as well as brain and lung cancers, lymphoma, and leukemia. The gene encoding the VC reductase, vcrA , is found on a mobile genetic element called the … Vinyl chloride (VC) is a human carcinogen that accumulates in soil and groundwater due to incomplete dechlorination of chlorinated ethenes. National Institute of Occupational Safety and Health. Vinyl chloride is also produced as a combustion product in tobacco smoke. Make sure the right personal protective equipment and clothing is used, like safety goggles, chemical resistant clothing and gloves (chemical resistant or insulated) and respirators. It can also irritate the eyes, skin, mucous membranes and respiratory tract. Lyon, France: World Health Organization, 2012. Vinyl chloride, the chemical used to make PVC, is a known human carcinogen, according to the World Health Organization’s International Agency for Research on Cancer (IARC). (1) Spread the word and invite others to become a friend of the roadmap. Studies in workers who have breathed vinyl chloride over many years showed an increased risk of liver, brain, lung cancer, and some cancers of the blood Here, we review … This toxic chemical is a known human carcinogen causing liver cancer, brain cancer and some cancers of the blood. They provide EPA staff with guidance for developing and using risk assessments. Chronic exposure leads to common forms of respiratory failure ( emphysema, pulmonary fibrosis) and focused hepatotoxicity ( … EPA has classified vinyl chloride as a Group A, human carcinogen. or the Agency’s) Guidelines for Carcinogen Risk Assessment, published in 51 FR 33992, September 24, 1986 (U.S. EPA, 1986a) and the 1999 interim final guidelines (U.S. EPA, 1999a; see U.S. EPA 2001b). This process is experimental and the keywords may be updated as the learning algorithm improves. If a water supply is contaminated, vinyl chloride can enter household air when the water is used for showering, cooking, or laundry. Together we can make a difference. The primary cause of Human carcinogen -- Vinyl Chloride is the result: at any time, from exposure to toxins, poisons, environmental, or other substances. There is sufficient evidence that vinyl chloride exposure causes angiosarcoma of the liver and hepatocellular carcinoma. Primary Cause of Human carcinogen -- Vinyl Chloride . Vinyl chloride is used primarily to make polyvinyl chloride (PVC); PVC is used to make a variety of plastic products, including pipes, wire and cable coatings, and packaging materials. Please Note: The main sources of information for this fact sheet are the Agency for Toxic Substances and Disease exposure to vinyl chloride via inhalation, as vinyl chloride exposure has been shown to increase the risk of a rare form of liver cancer in humans. Although the industries that use this chemical have known about the harmful effects of vinyl chloride for decades, it has only recently been identified as a known carcinogen. From: Systems Biology in Toxicology and Environmental Health, 2015. Vinyl chloride, from which PVC is manufactured, is a carcinogen and thus a hazard in PVC production. The International Agency for Research on Cancer has determined that vinyl chloride is carcinogenic to people, and EPA has determined that vinyl chloride is a human carcinogen. Uses [of PolyVinyl Chloride] Most of the vinyl chloride produced in the United States is used to make polyvinyl chloride (PVC), a material used to manufacture a variety of plastic and vinyl products including pipes, wire and cable coatings, and packaging materials. The association between 63. Vinyl chloride is a colorless gas that burns easily. Vinyl chloride is a Group 1 human carcinogen posing elevated risks of rare angiosarcoma, brain and lung tumors, and malignant haematopoeitic lymphatic tumors. Vinyl chloride is also a known genotoxicant, causing chemical alterations of DNA in tissues that may lead to cancer following exposure of humans and experimental animals (1, 2). Vinyl Chloride, NIOSH Pocket Guide to Chemical Hazards. (2) • EPA has classified vinyl chloride as a known human carcinogen by the inhalation route of exposure. Latency period between exposure and vinyl chloride related cancers varies strongly depending on the different types of cancer. The main route of occupational exposure to vinyl chloride is by inhalation, which occurs primarily in vinyl chloride/PVC plants and in PVC-processing plants (including packaging, storage and handling of vinyl chloride). At low exposure levels, the body is able to metabolize vinyl chloride and excrete it in urine. Vinyl Chloride Carcinogenic Potency Dose Response Data Animal Colony Fisher Exact Probability Test These keywords were added by machine and not by the authors. Children products including: water bottles, lunch boxes, toys, small chairs and tables, school bags and stationery items such as pencil boxes can contain some amounts of PVC. Instead, it is a manufactured substance produced by breaking down various other substances, gases, and chemicals. The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. Trichloroethylene (TCE) is a ubiquitous contaminant classified as a human carcinogen. Public … The U.S. Department of Health and Human Services has determined that vinyl chloride is a known carcinogen. Selected References: Agency for Toxic Substances and Disease Registry. Vinyl chloride is a highly dangerous chemical used to make numerous plastic materials. 1978), which suggests that vinyl bromide’s greater carcinogenic potency may be related to kinetic differences in metabolism. Vinyl Chloride is a known human carcinogen. 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