It does not occur naturally and must be produced industrially for its commercial uses. In 1974 vinyl chloride (VC), a gas used in the plastics industry, was shown to be a human carcinogen, inducing a very rare type of tumor, angiosarcoma of the liver. Vinyl Chloride, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100F. Industries at risk are manufacture of industrial chemicals, plastic products, fabricated metal products or machinery. vinyl chloride (by about an order of magnitude) (Bolt et al. EPA has classified vinyl chloride as a Group A, human carcinogen. At low exposure levels, the body is able to metabolize vinyl chloride and excrete it in urine. PVC—polyvinyl chloride, or vinyl—is found in a range of products, from children's toys to building materials to food packaging. Uses [of PolyVinyl Chloride] Most of the vinyl chloride produced in the United States is used to make polyvinyl chloride (PVC), a material used to manufacture a variety of plastic and vinyl products including pipes, wire and cable coatings, and packaging materials. Where risks occur The main route of occupational exposure to vinyl chloride is by inhalation, which occurs primarily in vinyl chloride/PVC plants and in PVC-processing plants (including packaging, storage and handling of vinyl chloride). Inform workers about the risks, appropriate resistant clothing and equipment and obligated preventive measures. But also in occupations or services allied to transport and construction. Spread the word and invite others to become a friend of the roadmap. Vinyl Halides (Selected), Report on Carcinogens, Fourteenth Edition. Public … Please Note: The main sources of information for this fact sheet are the Agency for Toxic Substances and Disease When present above the maximum concentration level (MCL) of 2 ppb, sites are unable to close and require continued remediation and monitoring. The gene encoding the VC reductase, vcrA , is found on a mobile genetic element called the … Perform proper exposure measurements so it is known when actions should be taken. 1978), which suggests that vinyl bromide’s greater carcinogenic potency may be related to kinetic differences in metabolism. Vinyl chloride has also been associated with mammary (breast) cancer. Agency for Toxic Substances and Disease Registry. Vinyl chloride (VC) is a flammable and explosive colourless gas with a sweet odour. If a water supply is contaminated, vinyl chloride can enter household air when the water is used for showering, cooking, or laundry. 62. The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. Vinyl chloride is a highly dangerous chemical used to make numerous plastic materials. Primary Cause of Human carcinogen -- Vinyl Chloride . Chronic exposure can cause permanent liver injury and liver cancer, neurologic or behavioral symptoms and changes to the skin and bones of the hand. Vinyl chloride does not occur in the environment naturally. Vinyl chloride is a colorless gas that burns easily. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Vinyl Chloride was originally published by the National Cancer Institute.”, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, U.S. Department of Health and Human Services. Most often used in construction, PVC is a plastic composed of three elements: carbon, hydrogen and chlorine. Vinyl chloride was carcinogenic to rats, mice and hamsters when administratered by oral inhalation or i.p. 63. injection routes, with increaed incidences of liver tumors, pulmonary angiosarcomas, extrahepatic abdominal angiosarcomas, and tumors of the Zymbal gland … The U.S. Occupational Safety & Health Administration provides information about exposure limits to vinyl chloride. Vinyl chloride is a colorless gas that burns easily. Vinyl chloride is a Group 1 human carcinogen posing elevated risks of rare angiosarcoma, brain and lung tumors, and malignant haematopoeitic lymphatic tumors. Primary exposure to vinyl chloride occurs through inhalation. Wang Q, Ji F, Sun Y, Qiu YL, Wang W, Wu F, et al. (2) • EPA has classified vinyl chloride as a known human carcinogen by the inhalation route of exposure. There is much data to substantiate a causal association between exposure to vinyl chloride and a distinctive form of liver cancer (angiosarcoma). substance or exposure is only on one agency’s list, this it does not necessarily mean there is a controversy, as one agency may not have evaluated Vinyl chloride (VC) is primarily used to manufacture polyvinyl chloride and can also be a degradation product of TCE. Vinyl Chloride Carcinogenic Potency Dose Response Data Animal Colony Fisher Exact Probability Test These keywords were added by machine and not by the authors. The carcinogenicity of the substance may be influenced by the nature (e.g. Vinyl chloride, the chemical used to make PVC, is a known human carcinogen, according to the World Health Organization’s International Agency for Research on Cancer (IARC). Employers shall ensure that each employee has access to labels on containers of vinyl chloride and to safety data sheets, and is trained in accordance with the requirements of HCS and paragraph (j) of this section. Co-carcinogens are chemicals that do not necessarily cause cancer on their own, but promote the activity of other carcinogens in causing cancer. Vinyl chloride is also produced as a combustion product in tobacco smoke. Vinyl chloride is classified as Group 1 carcinogen by the IARC, meaning it is seen as a definite cause of cancer in humans. Workers at facilities where vinyl chloride is produced or used may be exposed primarily through inhalation. Vinyl chloride is classified as Group 1 carcinogen by the IARC, meaning it is seen as a definite cause of cancer in humans. Employers shall include vinyl chloride in the hazard communication program established to comply with the HCS (§1910.1200). 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